Tag: 杭州十大名凤

FDA slaps clinical hold on Seattle Genetics after four patients die in cancer drug trial

FDA slaps clinical hold on Seattle Genetics after four patients die in cancer drug trial

first_img Four patients have died of liver toxicity while being treated with an experimental cancer drug from Seattle Genetics — leading the US Food and Drug Administration to place a handful of the company’s early stage clinical trials involving the treatment on hold.The drug, called vadastuximab talirine, was being tested in patients with acute myeloid leukemia — a cancer of the blood and bone marrow. More than 300 patients have been tested with this drug thus far, the company said in a statement. FDA slaps clinical hold on Seattle Genetics after four patients die in cancer drug trial By Meghana Keshavan Dec. 27, 2016 Reprints Meghana Keshavan What is it? What’s included? Tags cancerdrug developmentgeneticsSTAT+ Leukemia trials involving a monoclonal antibody treatment from Seattle Genetics are on hold after four deaths Anna Tanczos/Wellcome Images [email protected] GET STARTEDcenter_img Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. About the Author Reprints Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+. First 30 days free. GET STARTED Biotech STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Biotech Correspondent Meghana covers biotech and contributes to The Readout newsletter. @megkesh Log In | Learn More last_img read more

Industry groups respond to Basel consultation on internal risk models

Industry groups respond to Basel consultation on internal risk models

first_img Share this article and your comments with peers on social media Related news James Langton Basel revisions could lead to bank restructuring: report A collection of industry trade groups on Wednesday pushed back against efforts by the Basel Committee on Banking Supervision to reduce variation in the banks’ calculation of risk-weighted assets (RWAs), warning that this may end up harming financing activity, and ultimately, economic growth. The Global Financial Markets Association, the International Swaps and Derivatives Association, Inc., the International Association of Credit Portfolio Managers, and the Japan Financial Markets Council argue proposed changes to the Basel III capital adequacy regime designed to constrain banks’ use of internal models as a way of reducing variation in their calculations of RWAs “would distort capital allocation decisions and pricing to the detriment of banks’ customers and the global economy.” OSFI relaxes capital, liquidity requirementscenter_img In particular, the industry groups say that corporate lending, capital markets activity, project finance, along with aircraft, shipping, and commodities finance, would be impacted by the proposals. And economies where market financing is still developing “would also be likely to feel these effects more acutely,” the groups warn in a statement. The latest proposals from the Basel Committee are “leading to increased risk-weighted-asset levels, with decreasing marginal benefits for society,” the statement adds. The groups also argue that there are alternative ways for the regulators to reduce variation without restricting internal modeling to the extent that is being proposed. “This is particularly true as major investments on the part of both industry and the regulatory community are under way to reduce unwarranted differences in modelled outcomes,” the statement says. “These efforts should be allowed to take effect before fundamental changes are introduced.” Overall, the proposals “are more likely to increase the complexity of the capital framework and reduce comparability between firms,” the statement says. OSFI unwinds emergency pandemic relief measures Keywords Basel Capital Accord Facebook LinkedIn Twitterlast_img read more

Croatian tourist offer presented at New York Times Travel Show

Croatian tourist offer presented at New York Times Travel Show

first_imgFor the fourteenth year in a row, the Jacob K. Javits Conference Center was held New York Times Travel Show, the most visited tourism fair on the east coast of the United States, which opened from January 27-29.This year’s fair featured 500 exhibitors from 150 countries, of which as many as 40 percent are new exhibitors. In addition to the American representation of the Croatian Tourist Board, the fair was attended by the tourist boards of the City of Zagreb, Dubrovnik and Dubrovnik-Neretva County and two domestic companies, Katarina Line and Aktivni Odmor doo. it also included “Meet the Experts” workshops and numerous cultural and culinary performances on five cultural stages, which gathered more than 16 visitors and tourism professionals.Photo: Dubrovnik-Neretva Tourist Board”That Croatia is definitely a desirable tourist destination among American tourists is shown by the great interest shown in the destination presentations of Zagreb, Dubrovnik and Kvarner, which included award trips, as well as general attendance at the stands of Croatian representatives.” stand out from the CNTB. Also, the popularity of Croatia for the second year in a row is confirmed by an article published on the portal of the prestigious newspaper New York Time entitled “52 Places to Go in 2017”, and within which two Croatian destinations are listed – Dubrovnik in 6th place and Istria in 41st place.By the way, in 2016, an enviable number of tourists from the USA visited the Dubrovnik-Neretva County, 97.600, with 286.000 overnight stays and an increase of 10% compared to the year before.Related news:THE NEW YORK TIMES INCLUDES DUBROVNIK AND ISTRIA ON THE LIST OF THE 52nd WORLD TOURIST DESTINATIONS WORTH VISITING IN 2017last_img read more

Teen filmed friend’s suicide; said he had ‘fascination with death’

Teen filmed friend’s suicide; said he had ‘fascination with death’

first_img SHARE Do you see a typo or an error? Let us know. PAYSON CANYON, Utah (CBS) A Utah teen has been jailed on murder charges after police say he played an “active role” in a friend’s suicide, reports CBS affiliate KUTV.18-year-old Tyerell Joe Przybycien allegedly filmed as the 16-year-old girl hung herself from a tree, and he told police he had a “fascination with death,” the station reports.The Utah County Sheriff’s Office said Monday that turkey hunters found the victim dead, hanging from a tree Saturday morning near a wooded campground in Payson Canyon, south of Provo.When deputies responded, police say Przybycien approached them, told them he aided the girl’s suicide and wanted to see someone die, the station reports. Przybycien had purchased several items used “to facilitate the death” of the girl and had a cellphone recording of her as she died, the station reports.The recording on her cellphone showed the two of them talking about her suicide before she put a rope around her neck and inhaled a can of aerosol, the station reports. Deputies say Przybycien was still recording at the girl passed out and her weight caused her to hang from the rope and die.The video shows Przybycien approach her and check her pulse, but make no effort to help her, reports the Salt Lake Tribune.Police say they found a receipt for the aerosol and other items, purchased by Przybycien. The two also purchased the rope together, the paper reports.Police believe he left the scene of the girl’s death overnight before returning to talk to deputies the next morning.Przybycien was booked into the Utah County Jail on a murder charge. Bail has been set at $20,000. Published: May 9, 2017 3:19 PM EDT Updated: May 9, 2017 5:39 PM EDT Teen filmed friend’s suicide; said he had ‘fascination with death’ last_img read more

C’bean statisticians sign declaration for monitoring national public policies

C’bean statisticians sign declaration for monitoring national public policies

first_img Share Share Tweet Sharing is caring! NewsRegional C’bean statisticians sign declaration for monitoring national public policies by: Caribbean Media Corporation – November 20, 2015center_img Share 79 Views   no discussions Caribbean delegates at ECLAC meeting in EcuadorQUITO, Ecuador (CMC) – Caribbean statistical leaders have joined their counterparts from the Americas reaffirming their commitment to generating good-quality statistics for monitoring national public policies.The heads of statistics in the region signed the declaration that also allows them to re-affirm support for the 2030 Agenda for Sustainable Development that was approved at the United Nations General Assembly (UNGA) in September.The Mitads del Mundo Declaration was approved by the 36 delegations from member States and associate members of the Economic Commission for Latin America and the Caribbean (ECLAC) at the end of the eighth meeting of the Statistical Conference of the Americas (SCA) on Thursday.The declaration also urges the region’s governments to bolster their commitment to strengthening national statistical systems, establishing legal frameworks that provide professional independence to the national statistical offices, consolidate the leading role of official statistics and guarantee the human, technological and financial resources required.The text also calls on the international community to channel resources to this end, on the basis of cooperation, technical assistance and financial support.The three-day meeting also approved the resolutions recognizing the need to work jointly to design an implementation plan that enables the information requirements stemming from the 2030 Agenda to be covered gradually.Delegates also approved both the report on the implementation of the two-year programme for regional and international cooperation activities in 2014-2015 and the Conference’s 2015-2025 Strategic Plan. They requested that ECLAC make a proposal for a regional programme that meets the member States’ needs in terms of training and statistical education.In addition, the attendees agreed that the SCA’s Executive Committee for the 2016-2017 period will be made up of Mexico in the presidency, along with Belize, Costa Rica, Ecuador, Peru, Spain and Uruguay.last_img read more

USB-Controlled PLL Synthesizers for T&M Applications from 25 MHz to 27 GHz

USB-Controlled PLL Synthesizers for T&M Applications from 25 MHz to 27 GHz

first_imgFairview Microwave has launched a new line of USB-controlled, phase locked loop (PLL) frequency synthesizers. In RF and Microwave communications systems where signal integrity is a priority, PLL synthesizers that offer superior frequency stability and accuracy with exceptional phase noise characteristics allow components in the signal chain to perform at their optimal levels. These new PLL synthesizers are ideal for applications that involve electronic warfare, signal generators, benchtop test and measurement and microwave radios.Fairview’s six new PLL frequency synthesizer models are compact, rugged, SMA-connectorized designs that support USB 2.0 interface with a PC computer supplying DC power and GUI command control. They cover a broad range of frequency bands from 25 MHz to 27 GHz. These models deliver output attenuation that is adjustable up to 50 dB in 1 dB steps and high output power levels ranging from +10 dBm to +19 dBm typical. Phase noise is as low as -108 dBc/Hz at 100 MHz offset and phase locked speed is 1 msec typical.These synthesizer models also feature a 50 MHz internal frequency source and optional external reference with supplied cable. Frequency resolution can be adjusted using either integer (default) or fractional modes with resolution to a step size down to 1 MHz. Modules support RF power disable, phase locking and unlocking, and functional LED indicators that confirm a USB connection. These PLL frequency synthesizers are RoHS and Reach compliant and are classified as EAR99. A comprehensive user manual and VISA compliant software package can be downloaded from the Fairview website.  Fairview’s USB-controlled PLL synthesizers are in stock and ready for immediate shipment with no minimum order quantity. Click here for information on these products,.last_img read more